Antiplatelet drugs and oral anticoagulants are examples of antithrombotic medications and are among the most commonly prescribed drugs in both primary and secondary care
Aspirin causes direct damage to the gastric epithelium and inhibits prostaglandin production by the gastric mucosa, leading to ulcerations and an estimated 2-fold increased risk of GI bleeding with low-dose aspirin alone
the role of long-term combined therapy with aspirin and an antiplatelet The Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) trial was a randomized, double-blind, placebo-controlled trial in China that tested the hypothesis that three weeks of dual antiplatelet therapy with clopidogrel and ASA would decrease the risk of a recurrent stroke in comparison to ASA alone in patients Aspirin has been known for years to reduce recurrent strokes after the initial episode
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We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI
Antiplatelet agents—principally aspirin and clopidogrel, used alone or in combination—have been shown to reduce the risk of myocardial infarction (MI), ischaemic stroke, and cardiovascular death in patients with unstable angina, non–ST-elevation (NSTE)-acute coronary syndromes (ACS), and ST-elevation MI (STEMI)